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Here is the official Latisse safety page: Source 7 one of the permanent side effects is: LATISSE® use may cause darkening of the eyelid skin which may be reversible. LATISSE® use may also cause increased brown pigmentation of the colored part of the eye which is likely to be permanent. [See Similar Topics] Fashion Quote: Fashion, as we knew it, is over; people wear now exactly what they feel like wearing. -- Mary Quant